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主任研究者　衞藤義勝　発表論文

１９７０

  1. Suzuki K, Suzuki Y, Eto Y. Deficiency of galactocerebroside beta-galactoside in Krabbe｡ﾇs disease. In Lipid Storage Disease (Bernsoh and Grossman eds), Academic Press, New York. 1970; pp111-36
  2. Eto Y, Suzuki K, Suzuki K. Globoid cell leukodystrophy (Krabbe's disease): isolation of myelin with normal glycolipid composition. J Lipid Res. 1970; 11: 473-9.
  3. Eto Y, Kitagawa T. Wolman's disease with hypolipoproteinemia and acanthocytosis: clinical and biochemical observations. J Pediatr. 1970; 77: 862-7.

１９７１

  1. Eto Y, Suzuki K. Brain sphingoglycolipids in Krabbe's globoid cell leucodystrophy. J Neurochem. 1971; 18: 503-11.
  2. Eto Y, Suzuki K. Fatty acid composition of cholesterol esters in brains of patients with Schilder's disease, G M1 -gangliosidosis and Tay-Sachs disease, and its possible relationship to the -position fatty acids of lecithin. J Neurochem. 1971; 18: 1007-16.
  3. Eto Y, Suzuki K. Cholesterol ester metabolism in the brain: properties and subcellular distribution of cholesterol-esterifying enzymes and cholesterol ester hydrolases in adult rat brain. Biochim Biophys Acta. 1971; 239: 293-311.
  4. Eto Y, Suzuki K, Suzuki K. Lipid composition of rat brain myelin in triethyl tin-induced edema. J Lipid Res. 1971; 12: 570-9.
  5. Eto Y, Suzuki K. Globoid cell leukodystrophy(Krabbe｡ﾇs disease) : Isolation of myelin with normal glycolipid compositions. J. Lipid Res. 1971; 11: 473-5.

１９７２

  1. Eto Y, Suzuki K,. Cholesterol ester metabolism in rat brain; enzymes of cholesterol rster metabolism. J, Neurochem. 1972; 19: 117-20.
  2. Eto Y, Suzuki K,. Cholesterol ester metabolism; in its concentratio and fatty acids compositions. J. Neurochem. 1972; 19: 109-12.

１９７３

  1. Eto Y, Suzuki K. Cholesterol ester metabolism in rat brain. A cholesterol ester hydrolase specifically localized in the myelin sheath. J Biol Chem. 1973; 248: 1986-91.
  2. Suzuki K, Kamoshita S, Eto Y, Tourtellotte WW, Gonatas JO. Myelin in multiple sclerosis. Composition of myelin from normal-appearing white matter. Arch Neurol. 1973; 28: 293-7.
  3. Eto Y, Suzuki K. Developmental changes of cholesterol ester hydrolases localized in myelin and microsomes of rat brain. J Neurochem. 1973; 20: 1475-7.
  4. Eto Y, Suzuki K. Enzymes of cholesterol ester metabolism in the brain of mutant mice, quaking and jimpy. Exp Neurol. 1973; 41: 222-6.

１９７４

  1. Eto Y, Wiesmann UN, Carson JH, Herschkowitz NN. Multiple sulfatase deficiencies in cultured skin fibroblasts. Occurrence in patients with a variant form of metachromatic leukodystrophy. Arch Neurol. 1974; 30: 153-6.
  2. Eto Y, Rampini S, Wiesmann U, Herschkowitz NN. Enzymic studies of sulphatases in tissues of the normal human and in metachromatic leukodystrophy with multiple sulphatase deficiencies: arylsulphatases A, B and C, cerebroside sulphatase, psychosine sulphatase and steroid sulphatases. J Neurochem. 1974; 23: 1161-70.
  3. Eto Y, Wiesmann U, Herschkowit N. Sulfogalactosylsphingosine sulfatases: characteristics of the enzyme and its deficienc I metachromatic Keukodystrophy in human cultured skin fibroblasts. J. Biol. Chem. 1974; 49: 4955-60.

１９７６

  1. Eto Y, Meier C, Herschkowitz NN. Chemical compositions of brain and myelin in two patients with multiple sulphatase deficiency (a variant form of metachromatic leukodystrophy). J Neurochem. 1976; 2 7:1071-6.
  2. Eto Y, Enzymic studies of sulfatase deficiency to inborn error of metabolis and its variation to physical and mental development. US-Japan Cooperativ Medical Science Program.1976; 304-24.

１９７７

  1. Toyoda S, Eto Y, Aoki K. Bile lysosomal enzymes: characteristics and pathological significance for various hepatobiliary disorders. Clin Chim Acta. 1977; 79: 291-8.

１９７８

  1. Kiguchi K, Eto Y, Aoki K. Effects of macromolecular compounds on human leukocyte beta-galactosidase activity. Clin Chim Acta. 1978; 85: 151-7.
  2. Ohta H, Eto Y, Aoki K, Maekawa K. Glycoprotein associated with the development of nervous system. Brain and Develop. 1978; 3: 239-45.
  3. Eto Y, Owada M, Kitagawa T Kokubun Y. Neurochemical abnormality in I-cell disease; chemical analysis and? possible importance of beta-galactosidase deficiency. J. Neurochem. 1978; 32: 397-405.

１９７９

  1. Eto Y, Owada M, Kitagawa T, Kokubun Y, Rennert OM. Neurochemical abnormality in I-cell disease: chemical analysis and a possible importance of beta-galactosidase deficiency. J Neurochem. 1979; 32: 397-405.
  2. Eto Y, Numaguchi S, Handa T. Urinary acid mucopolysaccharides in multiple sulfatase deficiency (mucosulfatidosis). Eur J Pediatr. 1979; 132: 207-11.

１９８０

  1. Eto Y, Numaguchi S, Tahara T, Rennert OM. Multiple sulfatase deficiency (mucosulfatidosis): impaired degradation of labeled sulfated compounds in cultured skin fibroblasts in vivo.Eur J Pediatr. 1980; 135: 85-9.

１９８１

  1. Ito F, Ota H, Aoki K, Eto Y. Urocanic acid contents in histidinaemic infant and developing rat epidermis. J Inherit Metab Dis. 1981; 4: 55-6.
  2. Ohta H, Mori T, Eto Y, Maekawa K. Neonatal I-cell disease: clinical and biochemical observations. J Inherit Metab Dis. 1981; 4: 85-6.
  3. Ito F, Aoki K, Eto Y. Histidinemia: biochemical parameters for diagnosis. Am J Dis Child. 1981; 135: 227-9.
  4. Eto Y, et al, Tokoro T, Ito F. Chemical compositions of acid mucopolysaccharide in urine and tissues of patients with multiple sufatase deficiency. J. Inher Metab. Dis. 1981; 4: 161-2.
  5. Eto Y, Impaiment of sulfatied, Acid mucoplysacharide and cholesterol sulfate degration in cultured skin fibroblasts of patients with MSD. Acta Pediatr. Jap. 1981; 23: 101-6.

１９８２

  1. Eto Y, Tahara T, Koda N, Yamaguchi S, Ito F, Okuno A. Prenatal diagnosis of metachromatic leukodystrophy: a diagnosis by amniotic fluid and its confirmation. Arch Neurol. 1982; 39: 29-32.
  2. Eto Y, Tokoro T, Kureha Y, Koda N, Tada Y, Tahara T, Maekawa K, Liebaers I, Vamos E. Neonatal multiple sulphatase deficiency disorder: biochemical characterization. J Inherit Metab Dis. 1982; 5: 235-6.
  3. Eto Y, Tahara T, Koda N, Yamaguchi S. Prenatal diagnosis of metachromatic leukodystrophy: a diagnosis with amniotic fluid by DEAE-Sepharose column chromatography and its confirmation by kidney lipid analysis. J Inherit Metab Dis. 1982; 5: 77-8.
  4. Eto Y, Shinoda S. Gangliosides and neutral glycosphingolipids in human brain tumors: specificity and their significance. Adv Exp Med Biol. 1982; 152: 279-90.
  5. Ichinose E, Eto Y, Takechi T, Yoshioka F, Kato H. [Two-dimensional echocardiographic study of coronary artery lesion in Kawasaki disease: a new approach to visualize the right coronary artery] J Cardiogr. 1982; 12: 111-24.
  6. Eto Y, Tokoro T, Handa T, Herschkowitz NN, Rennert OM. Acid mucopolysaccharide (AMPS) abnormality in multiple sulfatase deficiency: chemical compositions of AMPS in urine and liver. Pediatr Res. 1982; 16: 395-9.
  7. Eto Y, Tokoro T, Liebaers I, Vamos E. Biochemical characterization of neonatal multiple sulfatase deficient (MSD) disorder cultured skin fibroblasts. Biochem Biophys Res Commun. 1982; 106: 429-34.
  8. Ida H, Umezawa F, Kasai E, Eto Y, Maekawa K. An accumulation of galactocerebroside in kidney from mouse globoid cell leukodystrophy (twitcher). Biochem Biophys Res Commun. 1982; 109: 634-8.
  9. Eto Y, Shinoda S. Ganglioside and neytral glycolipids in human brain tumors: specificity and their significance. New Vistas Glycolipid Research (Plenum Press) 1982; 279-89.

１９８３

  1. Eto Y, Shinoda S. Ganglioside and neytral glycolipids in human brain tumors: specificity and their significance. New Vistas Glycolipid Research (Plenum Press) 1982; 279-89.
  2. Eto Y, Umezawa F, Kasai E, Ida I, Maekawa KM. Biochemical studies in mouse Krabbe's disease (Twitcher). J Inherit Metab Dis. 1983; 6: 125-6.
  3. Eto Y, Tahara T, Tokoro T, Maekawa K. Various sulfatase activities in leukocytes and cultured skin fibroblasts from heterozygotes for the multiple sulfatase deficiency (mukosulfatidosis). Pediatr Res. 1983; 17: 97-100.
  4. Yamaguchi S, Eto Y. Diaminobenzidine peroxidase in rat brain. Exp Neurol. 1983; 80: 1-8.
  5. Yoshioka F, Eto Y, Hirata K, Rikitake N, Takechi T, Suzuki K, Ichinose E, Matsunaga S, Kato H. [Usefulness of contrast echoangiographic diagnosis of congenital tricuspid stenosis] J Cardiogr. 1983; 13: 383-94.
  6. Kiguchi K, Iwamori M, Nagai Y, Eto Y, Akatsuka J. Characterization of glycosphingolipids from cells of various types of human leukemia: occurrence of two glycosphingolipids, one reacting with anti-asialo GM1 antibody and one with anti-Forssman antibody. Gann. 1983; 74: 382-90.
  7. Kureha Y, Eto Y. A comparative study of brain arylsulfatases B1 and B2: the difference between the two forms in rates of uptake by multiple sulfatase deficient (MSD) disorder fibroblasts. J Biochem (Tokyo). 1983; 94: 1489-92.
  8. Eto Y, Kureha Y, Tada Y, Tokoro T, Maekawa K. Multiple sulfatase deficient disorder A-review of clinical and biochemical findings. Acta Pediatr. Jap. 1983; 25: 17-21.

１９８４

  1. Eto Y, Autilio-Gambetti L, McGrath JT. CanineGM2-gangliosidosis: chemical and enzymatic features. Adv Exp Med Biol. 1984; 174:431-40.
  2. Yamaguchi S, Koda N, Eto Y, Aoki K. Rapid screening of metabolic disease by proton NMR urinalysis. Lancet. 1984; 2: 284.
  3. Maekawa K, Shimizu H, Eto Y, Nonaka I. McArdler disease: familial variety of muscle phosphorylase activity in two siblings. Acta Pediatr. Jap 1984; 26: 10-5.

１９８５

  1. Matsushima H, Okuno A, Eto Y, Maekawa K. Neuropathologic study in the heterozygotes of X-linked brindled mutant mouse. Acta Neuropathol (Berl). 1985; 67: 300-8.
  2. Yamaguchi S, Okuno A, Eto Y, Maekawa K. Pathochemical study of a case of hereditary cerebral degenerative disease--lipopigment accumulation and peroxidase deficiency in brain. Tohoku J Exp Med. 1985; 145: 223-9.
  3. Umezawa F, Eto Y, Tokoro T, Ito F, Maekawa K. Enzyme replacement with liposomes containing beta-galactosidase from Charonia lumpas in murine globoid cell leukodystrophy (twitcher). Biochem Biophys Res Commun. 1985; 127: 663-7.
  4. Yamaguchi S, Koda N, Eto Y, Aoki K. Quick screening and diagnosis of organic acidemia by NMR urinalysis. J Pediatr. 1985; 106: 620-2.
  5. Tokoro T, Eto Y. Increased urinary excretion of acid mucopolysaccharides and glycopeptides in hypothyroidism following thyroid hormone therapy. Eur J Pediatr. 1985; 144: 84-6.
  6. Yamaguchi S, Okuno A, Eto Y, Maekawa K. Pathochemical study of a case of hereditary cerebral degernerative disease. Lipopingment accumulation and peroxidase deficiency. Tohoku J. Exp. Med 1985; 145: 84-6.

１９８６

  1. Tada Y, Sekiguchi S, Ito F, Eto Y. 4-Methylumbelliferyl lipase in human and mouse brain: a possible localization in myelin. J Neurochem. 1986; 46: 140-3.
  2. Ohashi T, Kanamoto Y, Yamaguchi S, Eto Y, Maekawa K. Abnormal excretion of autofluorescent lipids in urine from patients with neuronal ceroid lipofuscinosis. Tohoku J Exp Med. 1986; 148: 335-9.
  3. Kanamoto Y, Karashima H, Kim SU, Eto Y. Regulation of galactocerebroside and sulfatide synthesis by hormones in chick neural cultures. Brain Res. 1986; 371: 201-3.
  4. Yamaguchi S, Koda N, Ohashi T, Eto Y. Diagnosis of alkaptonuria by NMR urinalysis. Tohoku J. Exp Med. 1986; 150: 222-8.

１９８７

  1. Eto Y, Gomibuchi I, Umezawa F, Tsuda T. Pathochemistry, pathogenesis and enzyme replacement in multiple-sulfatase deficiency. Enzyme. 1987; 38: 273-9.
  2. Eto Y, Ida H, Umezawa F, Ohashi T, Gomibuchi I, Maekawa K. Partial deficiency of beta-hexosaminidase activity in canine GM2-gangliosidosis. Tohoku J Exp Med. 1987; 152: 333-8.
  3. Yamamoto H, Koda N, Yamaguchi S, Eto Y. Revised method of NMR urinalysis for detecting inborn error of metabolism. Clin. Chemistry. 1987; 33: 714.

１９８８

  1. Eto Y, Tsuda T, Ohhashi T, Yamaguchi S, Okuno A. Clinical and biochemical studies of Japanese neuronal ceroid-lipofuscinosis. Am J Med Genet Suppl. 1988;5:59-67.
  2. Umezawa F, Eto Y. Liposome targeting to mouse brain: mannose as a recognition marker. Biochem Biophys Res Commun. 1988; 153: 1038-44.
  3. Eto Y, Tada Y. Accumulation of phosphorus compounds in tissues and cultured skin fibroblasts in patients with hypophosphatasia. Biochem Biophys Res Commun. 1988; 154: 948-53.
  4. Hasegawa Y, Miyamoto K, Abe Y, Nakamura T, Sugino H, Eto Y, Shibai H, Igarashi M. Induction of follicle stimulating hormone receptor by erythroid differentiation factor on rat granulosa cell. Biochem Biophys Res Commun. 1988; 156: 668-74.

１９８９

  1. Ohashi T, Eto Y. Molecular analysis of Japanese Gaucher disease. J Inherit Metab Dis. 1989; 12: 355-8.
  2. Ida H, Eto Y, Maekawa K. Fetal GM1-gangliosidosis: morphological and biochemical studies. Brain Dev. 1989; 11: 394-8.
  3. Eto Y, Ida H, Matsui K. [Application of neuronal cell culture in human degenerative brain disorders] Hum Cell. 1989; 2: 156-64.
  4. Eto Y, Umezawa F. Liposomal therapy in lysosomal storage disease. Amer. J. Med. Genet.1989 ; 7: 89-92.

１９９０

  1. Ida H, Eto Y. Biochemical and morphological studies of dorsal root ganglion and its cultured cells from twitcher mouse (murine globoid cell leukodystrophy). Brain Dev. 1990; 12: 412-6.
  2. Shimizu H, Maekawa K, Eto Y. Abnormal urinary excretion of polyamines in HHH syndrome (hyperornithinemia associated with hyperammonemia and homocitrullinuria). Brain Dev. 1990; 12: 533-5.
  3. Matsui K, Shirasawa N, Eto Y. Cytoplasmic accumulations in rat primary brain cell cultures following treatment with E-64, a thiol protease inhibitor. Dev Neurosci. 1990; 12: 133-9.
  4. Ida H, Kusano K, Suzuki H, Tokoro T, Eto Y. Galactosylceramide and galactosylsphingosine loading studies in cultured skin fibroblasts in human and murine globoid cell leukodystrophy. Biochem Biophys Res Commun. 1990; 166: 1053-60.
  5. Ida H, Eto Y, Maekawa K. Biochemical pathogenesis of demyelination in globoid cell leukodystrophy (Krabbe's disease): the effects of psychosine upon oligodendroglial cell culture. Acta Paediatr Jpn. 1990; 32: 20-6.
  6. Toda K, Kobayashi T, Goto I, Ohno K, Eto Y, Inui K, Okada S. Lysosulfatide (sulfogalactosylsphingosine) accumulation in tissues from patients with metachromatic leukodystrophy. J Neurochem. 1990; 55: 1585-91.
  7. Sugama S, Kim SU, Ida H, Eto Y. Psychosine cytotoxicity in rat neural cell cultures and protection by phorbol ester and dimethyl sulfoxide. Pediatr Res. 1990; 28: 473-6.
  8. Tahara T, Eto Y, Kraus JP, Rosenberg LE. [Molecular basis of organic acidemia--propionic acidemia] Hum Cell. 1990; 3: 311-7.
  9. Ida H, Kawame F, Kim SU, Eto Y. Abnormality in cultured oligodendrocytes and Schwann cells isolated from the twitcher mouse. Mol Chem Neuropathol. 1990; 13: 195-204.
  10. Suzuki K, Tokoro T, Eto Y. Adnormality in cholesterol and sphingolipid metabolism in Niemann-Pick mice. Trans. Amer. Neurochem. 1990; 21: 109.

１９９１

  1. Sugama S, Eto Y, Yamamoto H, Kim SU. Psychosine cytotoxicity toward rat C6 glioma cells and the protective effects of phorbol ester and dimethylsulfoxide: implications for therapy in Krabbe disease. Brain Dev. 1991; 13: 104-9.
  2. Kawame H, Eto Y. A new glucocerebrosidase-gene missense mutation responsible for neuronopathic Gaucher disease in Japanese patients. Am J Hum Genet. 1991; 49: 1378-80.
  3. Eto Y, Kawame H, Nozawa M, Sugama S, Tokoro T. Biochemical and molecular studies of Gaucher disease. Brain dysfunction. 1991; 4: 244-51.

１９９２

  1. Sugama S, Matsunaga T, Ito F, Eto Y, Maekawa K. Transient, unilateral, isolated hypoglossal nerve palsy. Brain Dev. 1992; 14: 122-3.
  2. Nozawa M, Iwamoto T, Tokoro T, Eto Y. Novel procedure for measuring psychosine derivatives by an HPLC method. J Neurochem. 1992; 59: 607-9.
  3. Kawame H, Hasegawa Y, Eto Y, Maekawa K. Rapid identification of mutations in the glucocerebrosidase gene of Gaucher disease patients by analysis of single-strand conformation polymorphisms. Hum Genet. 1992; 90: 294-6.
  4. Sugama S, Ito F, Eto Y, Maekawa K. [A case of frontal lobe epilepsy presenting with gelastic seizures] No To Hattatsu. 1992 Sep; 24(5):475-9.
  5. Sugama S, Kusano K, Okazaki M, Eto Y. [The neuroendocrinological examinations in mentally retarded boy with self-injurious behavior (SIB) and the effect of naloxone, clomipramine and sulpiride on SIB] Rinsho Shinkeigaku. 1992 Aug;32(8):890-2.
  6. Sugama S, Tomita K, Okazaki M, Eto Y, Ito F, Maekawa K. [A patient with epilepsy presenting developmental regression after seizures--consideration of the mechanism from the findings of CT-scan and SPECT] No To Shinkei. 1992 May; 44(5):473-6.

１９９３

  1. Ohashi T, Eto Y, Learish R, Barranger JA. Correction of enzyme deficiency in metachromatic leukodystrophy fibroblasts by retroviral-mediated transfer of the human arylsulphatase A gene. J Inherit Metab Dis. 1993; 16: 881-5.
  2. Kawame H, Maekawa K, Eto Y. Molecular screening of Japanese patients with Gaucher disease: phenotypic variability in the same genotypes. Hum Mutat. 1993; 2: 362-7.
  3. Eto Y, Kawame H, Hasegawa Y, Ohashi T, Ida H, Tokoro T. Molecular characteristics in Japanese patients with lipidosis: novel mutations in metachromatic leukodystrophy and Gaucher disease. Mol Cell Biochem. 1993; 119: 179-84.
  4. Hasegawa Y, Kawame H, Eto Y. Mutations in the arylsulfatase A gene of Japanese patients with metachromatic leukodystrophy. DNA Cell Biol. 1993; 12: 493-8.
  5. Ida H, Rennert OM, Eto Y, Chan WY. Cloning of a human acid sphingomyelinase cDNA with a new mutation that renders the enzyme inactive. J Biochem (Tokyo). 1993; 114: 15-20.
  6. Sugama S, Okazaki M, Nakanishi Y, Ito F, Eto Y, Maekawa K. Well-developed infant with hypoxic-ischemic encephalopathy associated with EEG burst suppression and subcortical leukohypodensity on CT scan. Acta Paediatr Jpn. 1993; 35: 529-33.
  7. Tsuginoi S, Shanske S, Nonaka I, Eto Y, Mendell JR, Fenichel G, Dimaur S. Three new mutation in patients with myophosphorylase deficiency (McAdrdle disease). Amer. J. Hum Genet. 1993; 54: 44-52.
  8. Matsushima H, Eto Y, Maekwa K, Bogenmann E. Transfection of the prot-oncogene trk reconstitutes functional NGF signal pathway in human neuroblastoma. Neurochemical Res.1993; 18: 814.
  9. Hasegawa Y, Kawame H, Eto Y. [Molecular analysis of Japanese patients with metachromatic leukodystrophy] Nippon Rinsho. 1993 Sep;51(9):2314-8.
  10. Eto Y. [Signal cascade of NGF and its application in the treatment of brain injury and neural tumor] Tanpakushitsu Kakusan Koso. 1993 Aug; 38(10):1603-7.
  11. Sugama S, Nakanishi Y, Okazaki M, Ito F, Eto Y, Maekawa K. [SPECT (single photon emission computed tomography) findings in 4 cases of neuronal migration disorders] No To Shinkei. 1993 Jan; 45(1):39-42.

１９９４

  1. Yamamoto T, Ohashi T, Tokoro T, Maekawa K, Eto Y. Type C Niemann-Pick disease fibroblasts and their transformed cell lines are hypersensitive to HMG-CoA reductase inhibitors. J Inherit Metab Dis. 1994; 17: 718-23.
  2. Tsujino S, Shanske S, Nonaka I, Eto Y, Mendell JR, Fenichel GM, DiMauro S. Three new mutations in patients with myophosphorylase deficiency (McArdle disease). Am J Hum Genet. 1994; 54: 44-52.
  3. Yamamoto T, Tokoro T, Eto Y. The attenuated elevation of cytoplasmic calcium concentration following the uptake of low density lipoprotein in type C Niemann-Pick fibroblasts. Biochem Biophys Res Commun. 1994; 198: 438-44.
  4. Hasegawa Y, Kawame H, Ida H, Ohashi T, Eto Y. Single exon mutation in arylsulfatase A gene has two effects: loss of enzyme activity and aberrant splicing. Hum Genet. 1994; 93: 415-20.
  5. Matsunaga T, Hasegawa MM, Ryuno K, Omau S, Magara T, Kobayashi M, Machida K, Wakasugi H, Eto Y, Maekawa K. [On the antimicrobial activities of oral cephems against methicillin-sensitive Staphylococcus aureus isolated from children with pediatric infection] Jpn J Antibiot. 1994; 47: 485-92.
  6. Ida H, Rennert OM, Watabe K, Eto Y, Maekawa K. Pathological and biochemical studies of fetal Krabbe disease. Brain Dev. 1994; 16: 480-4.
  7. Yamamoto T, Hayashi Y, Suzuki H, Tahara T, Fujisawa K, Eto Y, Yamazaki Y, Maekawa K. Early onset of cecal perforation in neonatal, recto-sigmoid type Hirschsprung's disease. Acta Paediatr Jpn. 1994; 36: 717-9.
  8. Yamamoto T, Iwasawa K, Tokoro T, Eto Y, Maekawa K. [A possible same genetic defect in two Niemann-Pick disease model mice] No To Hattatsu. 1994 Jul; 26(4):318-22.
  9. Eto Y. [Inborn error of lipid metabolism] Ryoikibetsu Shokogun Shirizu. 1994; (4):619-30.

１９９５

  1. Yamaguchi M, Eto Y, Matsuzaki G, Ishii A, Shoji S, Takizawa H, Takaishi T, Inoue T, Nagaoka S, Ito K. [A case in which bronchorrhea was alleviated by oral erythromycin and inhalation of beclomethasone and furosemide] Nihon Kyobu Shikkan Gakkai Zasshi. 1995; 33: 192-6.
  2. Ida H, Iwasawa K, Kawame H, Rennert OM, Maekawa K, Eto Y. Characteristics of gene mutations among 32 unrelated Japanese Gaucher disease patients: absence of the common Jewish 84GG and 1226G mutations. Hum Genet. 1995; 95: 717-20.
  3. Ohashi T, Matalon R, Barranger JA, Eto Y. Overexpression of arylsulfatase A gene in fibroblasts from metachromatic leukodystrophy patients does not induce a new phenotype. Gene Ther. 1995; 2: 363-8.
  4. Ohashi T, Watabe K, Sato Y, Saito I, Barranger JA, Eto Y. Successful transduction of oligodendrocytes and restoration of arylsulfatase A deficiency in metachromatic leukodystrophy fibroblasts using an adenovirus vector. Gene Ther. 1995; 2: 443-9.
  5. Ohashi T, Tahara T, Fujisawa K, Hoshi Y, Ito F, Suzuki N, Eto Y, Maekawa K. Hurler syndrome with severe complication in post-bone marrow transplantation course: life threatening interstitial pneumonitis and hypertension. Acta Paediatr Jpn. 1995; 37: 697-700.
  6. Eto Y, Hasegawa Y, Tsuda T. [Metachromatic leukodystrophy (MLD) and Multiple sulphatase deficiency (MSD)] Nippon Rinsho. 1995 Dec; 53(12):2994-3003.

１９９６

  1. Ida H, Rennert OM, Maekawa K, Eto Y. Identification of three novel mutations in the acid sphinogomyelinase gene of Japanese patients with Niemann-Pick disease type A and B. Hum Mutat. 1996; 7: 65-7.
  2. Ohashi T, Watabe K, Sato Y, Saito I, Barranger JA, Matalon R, Eto Y. Gene therapy for metachromatic leukodystrophy. Acta Paediatr Jpn. 1996; 38: 193-201.
  3. Ida H, Rennert OM, Ito T, Maekawa K, Eto Y. Clinical and genetic studies of five fatal cases of Japanese Gaucher disease type 1. Acta Paediatr Jpn. 1996; 38: 233-6.
  4. Ida H, Rennert OM, Kawame H, Ito T, Maekawa K, Eto Y. Mutation screening of 17 Japanese patients with neuropathic Gaucher disease. Hum Genet. 1996; 98: 167-71.
  5. Sato T, Wada Y, Okazaki M, Kobayashi S, Okabe N, Eto Y, Kubo M, Maekawa K. [Study on septicaemia in infants and children in the past 20 years. Part 1. An analysis of causal organisms] Kansenshogaku Zasshi. 1996; 70: 775-83.
  6. Sato T, Wada Y, Okazaki M, Kobayashi S, Okabe N, Eto Y, Kubo M, Maekawa K. [Study on septicaemia in infants and children in the past 20 years. Part 2. An analysis of factors that prescribe for the prognosis] Kansenshogaku Zasshi. 1996; 70: 784-91.
  7. Tsuda T, Hasegawa Y, Eto Y. Two novel mutations in a Japanese patient with the late-infantile form of metachromatic leukodystrophy. Brain Dev. 1996; 18: 400-3.
  8. Mochizuki H, Joh K, Kawame H, Imadachi A, Nozaki H, Ohashi T, Usui N, Eto Y, Kanetsuna Y, Aizawa S. Mitochondrial encephalomyopathies preceded by de-Toni-Debre-Fanconi syndrome or focal segmental glomerulosclerosis. Clin Nephrol. 1996; 46: 347-52.
  9. Eto Y, Ida H. [Molecular studies of Gaucher disease] Rinsho Byori. 1996 Apr; 44(4):327-34.
  10. Eto Y. [Batten disease] Ryoikibetsu Shokogun Shirizu. 1996; (15):241-3.

１９９７

  1. Uyama E, Uchino M, Ida H, Eto Y, Owada M. D409H/D409H genotype in Gaucher-like disease. J Med Genet. 1997; 34: 175.
  2. Ohashi T, Watabe K, Uehara K, Sly WS, Vogler C, Eto Y. Adenovirus-mediated gene transfer and expression of human beta-glucuronidase gene in the liver, spleen, and central nervous system in mucopolysaccharidosis type VII mice. Proc Natl Acad Sci U S A. 1997; 94: 1287-92.
  3. Ida H, Rennert OM, Kawame H, Maekawa K, Eto Y. Mutation prevalence among 47 unrelated Japanese patients with Gaucher disease: identification of four novel mutations. J Inherit Metab Dis. 1997; 20: 67-73.
  4. Iwasawa K, Ida H, Eto Y. Differences in origin of the 1448C mutation in patients with Gaucher disease. Acta Paediatr Jpn. 1997; 39: 451-3.
  5. Sugama S, Yoshimura H, Ashimine K, Eto Y, Maekawa K. Enhanced magnetic resonance imaging of leptomeningeal angiomatosis. Pediatr Neurol. 1997; 17: 262-5.

１９９８

  1. Ida H, Rennert OM, Ito T, Maekawa K, Eto Y. Type 1 Gaucher disease: phenotypic expression and natural history in Japanese patients. Blood Cells Mol Dis. 1998; 24: 73-81.
  2. Yokoo T, Utsunomiya Y, Ohashi T, Imasawa T, Kogure T, Futagawa Y, Kawamura T, Eto Y, Hosoya T. Inflamed site-specific gene delivery using bone marrow-derived CD11b+CD18+ vehicle cells in mice. Hum Gene Ther. 1998; 9: 1731-8.
  3. Adachi Y, Kobayashi Y, Ida H, Yasumizu R, Okamura A, Kayatani H, Teranishi N, Inaba M, Sugihara A, Genba H, Eto Y, Ikehara S. An autopsy case of fetal Gaucher disease. Acta Paediatr Jpn. 1998; 40: 374-7.
  4. Kurosawa K, Ida H, Eto Y. Prevalence of arylsulphatase A mutations in 11 Japanese patients with metachromatic leukodystrophy: identification of two novel mutations. J Inherit Metab Dis. 1998; 21: 781-2.
  5. Ohashi T, Iizuka S, Sly WS, Machiki K, Eto Y. Efficient and persistent expression of beta-glucuronidase gene in CD34+ cells from human umbilical cord blood by retroviral vector. Eur J Haematol. 1998; 61: 235-9.
  6. Eto Y. [Lysosomal transport disorders: cystinosis and sialic acid storage disorders] Ryoikibetsu Shokogun Shirizu. 1998; (19 Pt 2):601-5.
  7. Eto Y, Ito T, Kobayashi H. [Multiple sulfatase deficiency] Ryoikibetsu Shokogun Shirizu. 1998; (19 Pt 2):385-8.
  8. Eto Y, Hasegawa Y, Kurosawa K. [Metachromatic leukodystrophy] Ryoikibetsu Shokogun Shirizu. 1998; (19 Pt 2):379-84.

１９９９

  1. Eto Y, Ida H. Clinical and molecular characteristics of Japanese Gaucher disease. Neurochem Res. 1999; 24: 207-11.
  2. Ida H, Rennert OM, Kato S, Ueda T, Oishi K, Maekawa K, Eto Y. Severe skeletal complications in Japanese patients with type 1 Gaucher disease. J Inherit Metab Dis. 1999; 22: 63-73.
  3. Miyata I, Eto Y, Kamijo T, Ogawa M, Futrakul A, Phillips JA 3rd. Screening for mutations in the GH-1 gene by dideoxy fingerprinting (ddF). Endocr J. 1999; 46 Suppl:S71-4.
  4. Oishi K, Ida H, Kurosawa K, Eto Y. Clinical and molecular analysis of Japanese patients with neuronal ceroid lipofuscinosis. Mol Genet Metab. 1999; 66: 344-8.
  5. Ida H, Rennert OM, Iwasawa K, Kobayashi M, Eto Y. Clinical and genetic studies of Japanese homozygotes for the Gaucher disease L444P mutation. Hum Genet. 1999; 105: 120-6.
  6. Ichiba T, Hoshi Y, Eto Y, Tajima N, Kuraishi Y. Characterization of GFR, a novel guanine nucleotide exchange factor for Rap1. FEBS Lett. 1999; 457: 85-9.
  7. Yoshimura K, Wakazono Y, Iizuka S, Morokawa N, Tada H, Eto Y.A Japanese patient homozygous for the H1085R mutation in the CFTR gene presents with a severe form of cystic fibrosis. Clin Genet. 1999; 56: 173-5.
  8. Yamasaki K, Sasaki T, Nemoto M, Eto Y, Tajima N.Differentiation-inducedinsulin secretion from nonendocrine cells with engineered human proinsulin cDNA. Biochem Biophys Res Commun. 1999; 265: 361-5.
  9. Yokoo T, Ohashi T, Utsunomiya Y, Kojima H, Imasawa T, Kogure T, Hisada Y, Okabe M, Eto Y, Kawamura T, Hosoya T. Prophylaxis of antibody-induced acute glomerulonephritis with genetically modified bone marrow-derived vehicle cells. Hum Gene Ther. 1999; 10: 2673-8.
  10. Sugama S, Namihira T, Matsuoka R, Taira N, Eto Y, Maekawa K. Psychiatric inpatients and chromosome deletions within 22q11.2. J Neurol Neurosurg Psychiatry. 1999; 67: 803-6.
  11. Tsukuno M, Suzuki H, Eto Y. Pfeiffer syndrome caused by haploinsufficient mutation of FGFR2. J Craniofac Genet Dev Biol. 1999; 19: 183-8.
  12. Miyata I, Eto Y, Kamijo T, Ogawa M, Futrakul A, Phillips JA 3rd. Screening for mutations in the GH-1 gene by dideoxy fingerprinting (ddF). Endocr J. 1999; 46 Suppl: S71-4.

２０００

  1. Urashima M, Suzuki H, Yuza Y, Akiyama M, Ohno N, Eto Y. An oral CD40 ligand gene therapy against lymphoma using attenuated Salmonella typhimurium. Blood. 2000; 95: 1258-63.
  2. Mochizuki H, Joh K, Matsuyama N, Imadachi A, Usui N, Eto Y. Focal segmental glomerulosclerosis in a patient with Prader-Willi syndrome. Clin Nephrol. 2000; 53: 212-5.
  3. Morokawa N, Iizuka S, Tanano A, Katsube A, Muraji T, Eto Y, Yoshimura K. Severe cystic fibrosis in a Japanese girl caused by two novel CFTR (ABCC7) gene mutations: M152R and 1540del10. Hum Mutat. 2000; 15: 485.
  4. Watabe K, Ohashi T, Sakamoto T, Kawazoe Y, Takeshima T, Oyanagi K, Inoue K, Eto Y, Kim SU. Rescue of lesioned adult rat spinal motoneurons by adenoviral gene transfer of glial cell line-derived neurotrophic factor. J Neurosci Res. 2000; 60: 511-9.
  5. Tsujino S, Kanazawa N, Ohashi T, Eto Y, Saito T, Kira J, Yamada T.Three novel mutations (G27E, insAAC, R179X) in the ORNT1 gene of Japanese patients with hyperornithinemia, hyperammonemia, and homocitrullinuria syndrome. Ann Neurol. 2000; 47: 625-31.
  6. Futagawa Y, Okamoto T, Ohashi T, Eto Y. Efficiency of adenovirus-mediated gene transfer into hepatocytes by liver asanguineous perfusion method. Res Exp Med (Berl). 2000; 199: 263-74.
  7. Ohashi T, Yokoo T, Iizuka S, Kobayashi H, Sly WS, Eto Y. Reduction of lysosomal storage in murine mucopolysaccharidosis type VII by transplantation of normal and genetically modified macrophages. Blood. 2000; 95: 3631-3.
  8. Sugama S, Bingham PM, Wang PP, Moss EM, Kobayashi H, Eto Y. Morphometry of the head of the caudate nucleus in patients with velocardiofacial syndrome (del 22q11.2). Acta Paediatr. 2000; 89: 546-9.
  9. Eto Y, Ohashi T. Gene therapy/cell therapy for lysosomal storage disease. J Inherit Metab Dis. 2000; 23: 293-8.
  10. Sakamoto T, Watabe K, Ohashi T, Kawazoe Y, Oyanagi K, Inoue K, Eto Y. Adenoviral vector-mediated GDNF gene transfer prevents death of adult facial motoneurons. Neuroreport. 2000; 11: 1857-60.
  11. Akiyama M, Yamada O, Akita S, Urashima M, Horiguchi-Yamada J, Ohno T, Mizoguchi H, Eto Y, Yamada H. Ectopic expression of c-myc fails to overcome downregulation of telomerase activity induced by herbimycin A, but ectopic hTERT expression overcomes it. Leukemia. 2000; 14: 1260-5.
  12. Suzuki Y, Isogai K, Teramoto T, Tashita H, Shimozawa N, Nishimura M, Asano T, Oda M, Kamei A, Ishiguro H, Kato S, Ohashi T, Kobayashi H, Eto Y, Kondo N. Bone marrow transplantation for the treatment of X-linked adrenoleukodystrophy. J Inherit Metab Dis. 2000; 23: 453-8.
  13. Hamano S, Tanaka M, Kawasaki S, Nara T, Horita H, Eto Y, Kohno S. Regional specificity of localized cortical lesions in West syndrome. Pediatr Neurol. 2000; 23: 219-24.
  14. Miyata K, Shimokawa H, Kandabashi T, Higo T, Morishige K, Eto Y, Egashira K, Kaibuchi K, Takeshita A. Rho-kinase is involved in macrophage-mediated formation of coronary vascular lesions in pigs in vivo. Arterioscler Thromb Vasc Biol. 2000; 20: 2351-8.
  15. Tsuda M, Kitasawa E, Ida H, Eto Y, Owada M. A newly recognized missense mutation in the GLUT2 gene in a patient with Fanconi-Bickel syndrome. Eur J Pediatr. 2000; 159: 867.
  16. Yagi T, Jikihara I, Fukumura M, Watabe K, Ohashi T, Eto Y, Hara M, Maeda M. Rescue of ischemic brain injury by adenoviral gene transfer of glial cell line-derived neurotrophic factor after transient global ischemia in gerbils. Brain Res. 2000; 885: 273-82.
  17. Eto Y, Ohno K, Tsukuno M. [Pfeiffer syndrome] Ryoikibetsu Shokogun Shirizu. 2000; (28 Pt 3):577.
  18. Eto Y. [Pelizaeus-Merzbacher disease(PMD)/spastic paraplegia 2(SPG2)] Ryoikibetsu Shokogun Shirizu. 2000; (29 Pt 4):536-7.
  19. Arita J, Maekawa K, Matsushima H, Eto Y, Harada T, Hano H, Morikawa T. [A patient with epilepsy, congenital alopecia and mental retardation: combination of atypical absence in waking and nocturnal partial seizure] No To Hattatsu. 2000 Jul; 32(4):312-7.

２００１

  1. Eto Y. [ Gaucher disease] Nippon Rinsho. 2001 Mar; 59 Suppl 3:317-21.
  2. Ida H, Rennert OM, Kobayashi M, Eto Y. Effects of enzyme replacement therapy in thirteen Japanese paediatric patients with Gaucher disease. Eur J Pediatr. 2001; 160: 21-5.
  3. Akiyama M, Kawame H, Ohashi H, Tohma T, Ohta H, Shishikura A, Miyata I, Usui N, Eto Y. Functional disomy for Xq26.3-qter in a boy with an unbalanced t(X;21)(q26.3;p11.2) translocation. Am J Med Genet. 2001; 99: 111-4.
  4. Yokoo T, Ohashi T, Utsunomiya Y, Shen JS, Hisada Y, Eto Y, Kawamura T, Hosoya T. Genetically modified bone marrow continuously supplies anti-inflammatory cells and suppresses renal injury in mouse Goodpasture syndrome. Blood. 2001; 98: 57-64.
  5. Watabe K, Sakamoto T, Ohashi T, Kawazoe Y, Oyanagi K, Takeshima T, Inoue K, Eto Y, Kim SU. Adenoviral gene transfer of glial cell line-derived neurotrophic factor to injured adult motoneurons. Hum Cell. 2001; 14: 7-15.
  6. Watabe K, Ida H, Uehara K, Oyanagi K, Sakamoto T, Tanaka J, Garver WS, Miyawaki S, Ohno K, Eto Y. Establishment and characterization of immortalized Schwann cells from murine model of Niemann-Pick disease type C (spm/spm). J Peripher Nerv Syst. 2001; 6: 85-94.
  7. Sugama S, Kimura A, Chen W, Kubota S, Seyama Y, Taira N, Eto Y. Frontal lobe dementia with abnormal cholesterol metabolism and heterozygous mutation in sterol 27-hydroxylase gene (CYP27). J Inherit Metab Dis. 2001; 24: 379-92.
  8. Shen JS, Watabe K, Ohashi T, Eto Y. Intraventricular administration of recombinant adenovirus to neonatal twitcher mouse leads to clinicopathological improvements. Gene Ther. 2001; 8: 1081-7.
  9. Yokoo T, Ohashi T, Utsunomiya Y, Shiba H, Shen JS, Hisada Y, Eto Y, Kawamura T, Hosoya T. Inflamed glomeruli-specific gene activation that uses recombinant adenovirus with the Cre/loxP system. J Am Soc Nephrol. 2001; 12: 2330-7.
  10. Shiba H, Okamoto T, Futagawa Y, Ohashi T, Eto Y. Efficientand cancer-selective gene transfer to hepatocellular carcinoma in a rat using adenovirus vector with iodized oil esters. Cancer Gene Ther. 2001; 8: 713-8.
  11. Sugama S, Soeda A, Eto Y. Magnetic resonance imaging in three children with kernicterus. Pediatr Neurol. 2001; 25: 328-31.
  12. Kuwashima N, Kageyama S, Eto Y, Urashima M. CD40 ligand immunotherapy in cancer: an efficient approach. Leuk Lymphoma. 2001; 42: 1367-77.
  13. Kimura T, Suzuki H, Ohashi T, Asano K, Kiyota H, Eto Y. The incidence of thanatophoric dysplasia mutations in FGFR3 gene is higher in low-grade or superficial bladder carcinomas. Cancer. 2001; 92: 2555-61.

２００２

  1. Akiyama M, Yamada O, Kanda N, Akita S, Kawano T, Ohno T, Mizoguchi H, Eto Y, Anderson KC, Yamada H.Telomerase overexpression in K562 leukemia cells protects against apoptosis by serum deprivation and double-stranded DNA break inducing agents, but not against DNA synthesis inhibitors. Cancer Lett. 2002; 178: 187-97.
  2. Eto Y, Ohashi T. Novel treatment for neuronopathic lysosomal storage diseases--cell therapy/gene therapy. Curr Mol Med. 2002; 2: 83-9.
  3. Akiyama M, Wada Y, Ando K, Miyata I, Usui N, Tanaka H, Inoue K, Eto Y. 11-year-old boy with sarcoidosis and generalized brawny induration of muscle. Pediatr Int. 2002 ; 44: 93-7.
  4. Shen JS, Meng XL, Ohashi T, Eto Y. Adenovirus-mediated prenatal gene transfer to murine central nervous system. Gene Ther. 2002; 9: 819-23.
  5. Shen JS, Watabe K, Meng XL, Ida H, Ohashi T, Eto Y. Establishment and characterization of spontaneously immortalized Schwann cells from murine model of globoid cell leukodystrophy (twitcher). J Neurosci Res. 2002; 68: 588-94.
  6. Uehara R, Suzuki H, Kurokawa N, Urashima T, Fujiwara M, Matoba M, Eto Y. Novel nonsense mutation of the BMPR-II gene in a Japanese patient with familial primary pulmonary hypertension. Pediatr Int. 2002; 44: 433-5.

２００３

  1. Hakuba N, Watabe K, Hyodo J, Ohashi T, Eto Y, Taniguchi M, Yang L, Tanaka J, Hata R, Gyo K. Adenovirus-mediated overexpression of a gene prevents hearing loss and progressive inner hair cell loss after transient cochlear ischemia in gerbils. Gene Ther. 2003; 10: 426-33.
  2. Yoshimura K, Anzai C, Iizuka S, Eto Y, Heda GD. Molecular biological study of action mechanismof macrolide antibiotics on CFTR. Jpn J Antibiot. 2003; 56 Suppl A: 117-20.
  3. Anzai C, Morokawa N, Okada H, Kamidono S, Eto Y. CFTR gene mutations in Japanese individualswith congenital bilateral absence of the vas deferens. J Cyst Fibros. 2003; 2:14-8.
  4. Sugama S, Ariga M, Hoashi E, Eto Y. Brainstem cranial-nerve lesions inan infant with hypoxic cerebral injury. Pediatr Neurol. 2003; 29:256-9.
  5. Kimura T, Ohashi T, Kikuchi T, Kiyota H, Eto Y, Ohishi Y. Antitumor immunity against bladder cancer induced by ex vivo expression of CD40 ligand gene using retrovirus vector. Cancer Gene Ther. 2003; 10:833-9.
  6. Meng XL, Shen JS, Ohashi T, Maeda H, Kim SU, Eto Y. Brain transplantation of genetically engine-neered human neural stem cells globally corrects brain lesions in the mucopolysaccharidosis type VII mouse. J Neurosci Res. 2003; 74:266-77.
  7. Hamano S,Tanaka M, Mochizuki M, Sugiyama N, Eto Y. Long-term follow-up study of West syndrome:Differences of outcome among symptomatic etiologies. J Pediatr. 2003; 143:231-5.
  8. Hamano S, Tanaka M, Mochizuki M, Sugiyama N, Eto Y. Midazolam treatment for status epilepticus of children. No to Hattatsu. 2003; 35:304-9.
  9. Kobayashi H, Fujisawa K, SaitoY, KamijoM, Oshima S, Kubo M, Eto Y, Monma C, Kitamura M. A botulism case of a 12-year-old girl caused by intestinal colonization of Clostridium botulinum type Ab. Jpn J Infect Dis. 2003; 56:73-4.
  10. Sugama S, Eto Y. Brainstem lesions in children with perinatal brain injury. Pediatr Neurol. 2003; 28: 212-5.
  11. Arita J, Tomikawa M, Matsushima H, Eto Y,Morikawa T. Rhythmic fast activity on EEG in a patient with Mollaret｡ﾇs meningitis. No to Hattatsu. 2003; 35:239-42.
  12. Hakuba N, Watabe K, Hyodo J, Ohashi T, Eto Y, Taniguchi M, Yang L, Tanaka J, Hata R, Gyo K. Adenovirus-mediated overexpression of a gene prevents hearing loss and progressive inner hair cell loss after transient cochlear ischemia in gerbils. Gene Ther. 2003; 10: 426-33.
  13. Sakamoto T, Kawazoe Y, Shen JS, Takeda Y, Arakawa Y, Ogawa J, Oyanagi K, Ohashi T, Watanabe K, Inoue K, Eto Y, Watabe K. Adenoviral Gene Transfer of GDNF, BDNF and TGFｦﾂ2, but not CNTF, cardiotrophin-1 or IGF1, protects injured adult motoneurons after facial nerve avulsion. J Neurosci Res. 2003 ; 72:54-64.

２００４

  1. Akiyama M, Yamada O, Hideshima T, Yanagisawa T, Yokoi K, Fujisawa K, Eto Y, Yamada H, Anderson KC. TNFalpha induces rapid activation and unclear translocation of telomerase in fuman lymphocytes. Biochem Biophys Res Commun. 2004; 316(2): 528-32.
  2. Miyata I, Yoshikawa H, Eto Y. Consitutionally tall stature with morphological abnormality of the pituitary gland. Endocr J. 2004; 51:189-95.
  3. Eto Y, Shen JS, Meng XL, Ohashi T. Treatment of lysosomal storage disorders: cell therapy and gone therapy. 2004; J Inherit Metab Dis. 27-411-5.
  4. Hamanoue M, Yoshioka A, Ohashi T, Eto Y, Takamatsu K. NF-kappakB prevents TNF-alpha-induced apoptosis in an oligodendrc cell line. 2004; 29: 1571-6.
  5. Lin H, Sugimoto Y, Ohsaki Y, Ninomiya H, Oka A, Taniguchi M, Ida H, Eto Y, Ogawa S, Matsuzaki Y, Sawa M, Inoue T, Higaki K, Nanba E, Ohno K, Suzuki Y. N-octyl-beta-valienamine up-regulates activity of F213I mutant beta-glucosidase in cultured cells: a potential chemical chaperone therapy for Gaucher disease. Biochim Biophys Acta. 2004; 1689: 219-228.
  6. Sakurai K, Iizuka S, Shen JS, Meng XL, Mori T, Umezawa A, Ohashi T, Eto Y. Brain transplantation of genetically modified bone marrowstromal cells corrects CNS pathology and cognitive function in MPS VII mice. Gene Ther. 2004; 11: 1475-1481.
  7. Kato Y, Yano I, Ito F, Yanagisawa T, Hoshi Y, Eto Y. Home-based palliative care for children with cancer in Japan, present issues and future prospects. Pediatr Int. 2004; 46: 478-479.
  8. Shen JS, Meng XL, Maeda H, Ohashit, Eto Y. Widespread gene transduction to the central nervous system by adenovirous in utero: implication for prenatal gene theraphy to brain involvement of lysosomal storage disease. J Gene Med. 2004; 6:1206-12015.
  9. Hashimoto M, Fukuda T, Shimizu T, Watanabe S, Watanuki S, Eto Y, Urashima M. Influence of climate factors on emergency visits for childhood asthma attack. Pediatr Int. 2004 Feb;46(1):48-52.

２００５

  1. Yokoi K, Akiyama M, Yanagisawa T, Yoshino M, Nakazaki H, Takahashi K, Takahashi-Fujigasaki J, Kanetsuma Y, Yamada H, Oi S, Eto Y. RNA expression analysis of a congenatiral intracranian teratoma. Pediatr Blood Cancer. 2005; 7: 516-520.
  2. Shen JS, Meng XL, YokooT, Sakurai K, Wanabe K, Ohashi T, Eto Y. Widespread and highly persistent gene transfer to the CNS by retrovirus vectorin utero: implication for gene therapy to Krabbe disease. J Gene Med. 2005; 7: 540-551.
  3. Fujimoto K, Sasaki T, Nemoto M, Nakai N, Sakai K, Yamasaki K, Hiki Y, Ohashi T, Eto Y, Tajima N. Enhanced insulim secretion from engineered 3T3-L1 preadipocytas by induction of cellular differentiation. Mol Cell Biochem. 2005; 268: 1-8.
  4. Yokoo T, Ohashi T, Shen JS, Sakurai K, Miyazaki Y, Utsunomiya Y, Takahashi M, Terada Y, Eto Y, Kawamura T, Osumi N, Hosoya T. Human mesenchymal stem cells in rodent whole-embryo culture are reprogrammed to contribute to kidney tissuete. Proc Natl Acad Sci U.S.A. 2005; 102: 3296-3300.
  5. Urashima M, Sakuma M, Teramoto S, Fuyama Y, Eto Y, Kondo K, Tanaka T. Gene expression profiles of peripheral and cord blood mononuclear cells altered by thymic stromal lymphopoietim. Pediatr Res. 2005; 57: 563-9.
  6. Meng XL, Shen JS, Watabe K, Ohashi T, Eto Y. GALK transduction leads to morphological improvement of the twitcher oligodendrocytes in vivo. Mol Genet Metab. 2005; 84: 332-343.
  7. Akiyama M, Yanagisawa T, Yuza Y, Yokoi K, Ariga M, Fujisawa K, Hoshi Y, Eto Y. Successful treatment of Diamond-Blackfan anemia with tetoclopramide. Am J Hematol. 2005; 78: 295-298.
  8. Eto Y, Ohashi T, Utsunomiya Y, Fujiwara M, Mizuno A, Inui K, Sakai N, Kitagawa T, Suzuki Y, Mochizuki S, Kawakami M, Hosoya T, Owada M, Sakuraba H, Saito H. Enzyme replacement therapy in Japanese Fabry disease patients: the results of a phase 2 bridging study. J Inherit Metab Dis. 2005; 28: 575-583.
  9. Akiyama M, Yanagisawa T, Yuza Y, Yokoi K, Fujisawa K, Kobayashi S, Eto Y. Severe aplastic anaemia complicating Sjogren syndrome in a 2-year-old girl. Eur J Pediatr. 2005; 164: 700-702.
  10. Kitagawa T, Ishige N, Suzuki K, Owada M, Ohashi T, Kobayashi M, Eto Y, Tanaka A, Mills K, Winchester B, keutzer J. Non-invasive screening method for Fabry disease by measuring globotriaosylceramide in whole urine saples using tandem mass spectrometry. Mol Genet Metab. 2005; 85: 196-202.
  11. Kurihara M, Nakae Y, Kohagizawa T, Eto Y. Brain perfusion single photon emissioncomputed tomography in children after acte encephalopathy. No To Hattatsu. 2005; 37: 289-292.
  12. Teramoto S, Uchiyama M, Higurashi N, Wada Y, Kubo M, Eto Y. A case of isolated retrogradde amnesia following brain concussion. Pediatr Int. 2005; 47: 462-472.
  13. Yoshinari S, Hamano S, Ito T, Eto Y. MRI-diffusion weighted images of encephalopathy associated with human herpesvirus 6 infection. No To Hattatsu. 2005; 37: 374-379.
  14. Hamano S, Sugiyama N, Tanaka M, Kikuchi K, Eto Y. Choice and administration sequence of antiepileptic agents for status epileptics and frequentseizures in children. No To Hattatsu. 2005; 37: 395-399.
  15. Ichinose M, Nakayama M, Ohashi T, Utsunomiya Y, Kobayashi M, Eto Y. Significance of screening for Fabry disease among male dialysis patients. Clin Exp Nephrol. 2005; 9: 228-232.
  16. Tanaka M, Ohashi T, Kobayashi M, Eto Y, Miyamura N, Nishida K, Araki E, Itoh K, Matsushita K, Hara M, Kuwahara K, Nakano T, Yasumoto N, Nonoguchi H, Tomita K. Identification of Fabry｡ﾇs disease by the screening of alpha-galactosidase A activity in male and female homodialysis patients. Clin Nephrol. 2005; 64: 281-287.
  17. Yuza Y, Yokoi K, Sakurai K, Ariga M, Yanagisawa T, Ohashi T, Hoshi Y, Eto Y. Allogenic bone marrow transplantation for late-infantile neuronal ceroic lipofuscinosis. Pediatr Int. 2005; 47: 681-683.
  18. Akiyama M, Kobayashi N, Fujisawa K, Eto Y. Disseminated Varicella-Zoster virus infection in a girl with T-lineage acute lymphoblastic leukemia. Pediatr Blood Cancer. 2005 Aug; 45(2):191-4.

２００６

  1. Akiyama M, Murayama S, Yokoi K, Yanagisawa T, Hattori Y, Yamashiro Y, Eto Y, Fujisawa K. Hemoglobin Hammersmith [beta 42(CD1) Phe --> Ser] causing severe hemolytic anemia in a Japanese girl. Pediatr Blood Cancer. 2006 Nov; 47(6):839-41.
  2. Sasaki K, Uno K, Ebihara A, Komuro T, Eto Y, Iida H, Takenaka K. [Unusual echo-free space behind the left atrium] J Cardiol. 2006 Jan; 47(1):47-9.
  3. Hamano S, Sugiyama N, Yamashita S, Tanaka M, Hayakawa M, Minamitani M, Yoshinari S, Eto Y. Intravenous lidocaine for status epilepticus during childhood. Dev Med Child Neurol. 2006 Mar; 48(3):220-2.
  4. Mikami-Terao Y, Akiyama M, Yanagisawa T, Takahashi-Fujigasaki J, Yokoi K, Fukuoka K, Sakuma M, Miyata I, Fujisawa K, Oi S, Eto Y. Lymphocytic hypophysitis with central diabetes insipidus and subsequent hypopituitarism masking a suprasellar germinoma in a 13-year-old girl. Childs Nerv Syst. 2006 Oct; 22(10):1338-43.
  5. Hamano S, Yamashita S, Tanaka M, Yoshinari S, Minamitani M, Eto Y. Therapeutic efficacy and adverse effects of adrenocorticotropic hormone therapy in west syndrome: differences in dosage of adrenocorticotropic hormone, onset of age, and cause. J Pediatr. 2006 Apr; 148(4):485-8.
  6. Suzuki H, Akiyama N, Tsuji M, Ohashi T, Saito S, Eto Y. Human Shugoshin mediates kinetochore-driven formation of kinetochore microtubules. Cell Cycle. 2006 May;5(10):1094-101. Epub 2006 May 15.
  7. Higurashi N, Hamano S, Eto Y. [Secondary progressive multiple sclerosis in childhood--interferon beta 1b treatment] No To Hattatsu. 2006 May; 38(3):209-13.
  8. Shiba H, Okamoto T, Futagawa Y, Misawa T, Yanaga K, Ohashi T, Eto Y. Adenovirus vector-mediated gene transfer using degradable starch microspheres for hepatocellular carcinoma in rats. J Surg Res. 2006 Jun 15; 133(2):193-6.
  9. Mizuno Y, Furusho T, Yoshida A, Nakamura H, Matsuura T, Eto Y. Serum vitamin A concentrations in asthmatic children in Japan. Pediatr Int. 2006 Jun; 48(3):261-4.
  10. Yokoi K, Akiyama M, Yanagisawa T, Takahashi-Fujigasaki J, Yokokawa Y, Mikami-Terao Y, Fukuoka K, Fujisawa K, Nakazaki H, Oi S, Eto Y, Yamada H. Sequential analysis of cadherin expression in a 4-year-old girl with intracranial ependymoma. Childs Nerv Syst. 2006 Aug 25
  11. Miyata I, Vallette-Kasic S, Saveanu A, Takeuchi M, Yoshikawa H, Tajima A, Tojo K, Reynaud R, Gueydan M, Enjalbert A, Tajima N, Eto Y, Brue T. Identification and functional analysis of the novel S179R POU1F1 mutation associated with combined pituitary hormone deficiency. J Clin Endocrinol Metab. 2006 Dec; 91(12):4981-7.
  12. Yoshikawa H, Miyata I, Eto Y. Serum glucagon-like peptide-2 levels in neonates: comparison between extremely low-birthweight infants and normal-term infants. Pediatr Int. 2006 Oct; 48(5):464-9.
  13. Kato Y, Takano Y, Kobayashi M, Ito F, Hara T, Yanagisawa T, Hoshi Y, Eto Y. Retinochoroidal infarction during the treatment of acute lymphoblastic leukemia. Pediatr Int. 2006 Oct; 48(5):495-7.
  14. Eto Y. [Lisosomal disease with endocrine abnormality] Nippon Rinsho. 2006 Sep 28; Suppl 3:579-81.
  15. Shibata A, Katsunuma T, Tomikawa M, Tan A, Yuki K, Akashi K, Eto Y. Increased leukotriene E4 in the exhaled breath condensate of children with mild asthma. Chest. 2006 Dec; 130(6):1718-22.
  16. Yokoi K, Akiyama M, Yanagisawa T, Takahashi-Fujigasaki J, Yokokawa Y, Mikami-Terao Y, Fukuoka K, Fujisawa K, Nakazaki H, Oi S, Eto Y, Yamada H. Sequential analysis of cadherin expression in a 4-year-old girl with intracranial ependymoma. Childs Nerv Syst. 2007 Feb; 23(2):237-42.
  17. Mizuno Y, Furusho T, Yoshida A, Nakamura H, Matsuura T, Eto Y. Serum vitamin A concentrations in asthmatic children in Japan. Pediatr Int. 2006 Jun; 48(3):261-4.
  18. kiyama M, Yamada O, Yanagisawa T, Fujisawa K, Eto Y, Yamada H. Analysis of telomerase activity and RNA expression in a patient with acute promyelocytic leukemia treated with all-trans retinoic acid. Pediatr Blood Cancer. 2006 Apr; 46(4):506-11.

２００７

  1. Fujimoto K, Sasaki T, Hiki Y, Nemoto M, Utsunomiya Y, Yokoo T, Nakai N, Ohashi T, Hosoya T, Eto Y, Tajima N. In vitro and Pathological Investigations of MODY5 with the R276X-HNF1beta (TCF2) Mutation.Endocr J. 2007 Dec; 54(5):757-64.
  2. Nemoto M, Nishimura R, Sasaki T, Hiki Y, Miyashita Y, Nishioka M, Fujimoto K, Sakuma T, Ohashi T, Fukuda K, Eto Y, Tajima N. Genetic association of glutathione peroxidase-1 with coronary artery calcification in type 2 diabetes: a case control study with multi-slice computed tomography. Cardiovasc Diabetol. 2007 Sep 7; 6:23.
  3. Ohashi T, Sakuma M, Kitagawa T, Suzuki K, Ishige N, Eto Y. Influence of antibody formation on reduction of globotriaosylceramide (GL-3) in urine from Fabry patients during agalsidase beta therapy.Mol Genet Metab. 2007 Nov; 92(3):271-3.
  4. Miyata I, Yoshikawa H, Ikemoto M, Eto Y. Right testicular necrosis and left vanishing testis in a neonate. J Pediatr Endocrinol Metab. 2007 Mar; 20(3):449-54.
  5. Miyata I, Abe-Gotyo N, Tajima A, Yoshikawa H, Teramoto S, Seo M, Kanno K, Sugiura K, Tanaka T, Eto Y. Successful Intrauterine Therapy Goitrous Hypothroidism during Late Gestation. Endocr J. 2007 Dec;54(5):813-7
  6. Lei K, Ninomiya H, Suzuki M, Inoue T, Sawa M, Iida H, Eto Y, Ogawa S, Ohno K, Suzuki Y. Enzyme enhancement activity of N-octyl-beta-valienamine on beta-glucosidase multants associates with Gaucher disease. Biochim Biophys Acta. 2007 May;1772(5):587-96.
  7. Hamano S, Yoshinari S, Higurashi N, Tanaka M, Minamitani M, Eto Y. Developmental outcomes of cryptogenic West syndrome. J Pediatr Endocrinol Metab. 2007 Mar; 150(3):295-9.
  8. Hamano S, Yoshinari S, Higurashi N, Tanaka M, Minamitani M, Eto Y. Regional cerebral blood flow and developmental outcomein cryptogenic West syndrome. Epilepsia. 2007 Ja

２００８

  1. Ohashi T, Iizuka S, Ida H, Eto Y. Reduced alpha-Gal A enzyme activity in Fabry fibroblast cells and Fabry mice tissues induced by serum from antibody positive patients with Fabry disease. Mol Genet Metab. 2008; 94(3):313-8.
  2. Kobayashi M, Ohashi T, Sakuma M, Ida H, Eto Y. Clinical manifestations and natural history of Japanese heterozygous females with Fabry disease. J Inherit Metab Dis. 2008 Jan 21
  3. Scarpa M, Eto Y. Lysosomal storage diseases: new challenges.Acta Paediatr Suppl. 2008 Apr; 97(457):5-6.
  4. Eto Y.: New trends in child neurology. No To Hattatsu. 2008 May; 40(3):190. Japanese.
  5. Higurashi N, Hamano S, Yoshinari S, Tanaka M, Minamitani M, Eto Y.: Epileptic spasms without hypsarrhythmia showing astatic seizures in clusters. No To Hattatsu. 2008 Jan;40(1):49-53. Japanese.
  6. Shiba H, Misawa T, Ohashi T, Eto Y, Yanaga K. : Adenovirus-mediated CD40L gene therapy induced both humoral and cellular immunity against rat model of hepatocellular carcinoma. Cancer Sci. 2008 Oct; 99(10):2097-103.

２００９

  1. Tajima A, Yokoi T, Ariga M, Ito T, Kaneshiro E, Eto Y, Ida H. : Clinical and genetic study of Japanese patients with type 3 Gaucher disease.Mol Genet Metab. 2009 Aug; 97(4):272-7.
  2. Hagiwara S, Fujimaru T, Ogino A, Takano T, Sekijima T, Kagimoto S, Eto Y. : Lung abscess caused by infection of Actinobacillus actinomycetemcomitans. Pediatr Int. 2009 Oct;51(5):748-51.
  3. Nagashima T, Kobayashi M, Teramoto S, Okano E, Yokoi T, Eto Y. : Extremely low-birthweight neonate with prenatal Campylobacter infection. Pediatr Int. 2009 Oct; 51(5):746-8.
  4. Eto Y : Genome research in pediatric field. Nippon Rinsho. 2009 Jun; 67(6):1146-55. Japanese
  5. Sakurai Y, Suzuki R, Yoshida R, Kojima H, Watanabe M, Manome Y, Ohashi T, Eto Y, Moriyama H. Inner ear pathology of alpha-galactosidase A deficient mice, a model of Fabry disease. Auris Nasus Larynx. 2009：1303；1-7
  6. Sakurai Y, Kojima H, Shiwa M, Ohashi T, Eto Y, Moriyama H. The hearing status in 12 female and 15 male Japanese Fabry patients. Auris Nasus Larynx. 2009; 36(6):627-32.

２０１０

  1. Kobayashi H, Takahashi-Fujigasaki J, Fukuda T, Saurai K, Shimada Y, Nomura K, Ariga M, Ohashi T, Eto Y, Otomo T, Sakai N,Ida H: Pathology of the first autopsy case diagnosed as mucolipidosis typeIII alpha/beta suggesting autophagicdy function. , Mol Genet Metab.102 (2011) 170-175
  2. Ohashi T, Iizuka S, Shimada Y, Eto Y, Ida H, Hachimura S, Kobayashi H：Oral administration of recombinant human acid α-glucosidase reduces specific antibody formation against enzyme in mouse. , Mol Genet Metab. 2011 Jan 27.
  3. Kobayashi H, Shimada Y, Ikegami M, Kawai T, Sakurai K, Urashima T, Ijima M, Fujiwara M, Kaneshiro E, Ohashi T, Eto Y, Ishigaki K, Osawa M, Kyosen SO, Ida H.：Prognostic factors for the late onset Pompe disease with enzyme replacement therapy: from our experience of 4 cases including an autopsy case. Mol Genet Metab. 2010 May;100(1):14-9. Epub 2010 Feb 4.
  4. Eto Y.：Single gene disorder: recent advances of research. Nippon Rinsho. 2010 Aug; 68 Suppl 8:117-28. Japanese.
  5. Kyosen OS, Iizuka S, Kobayashi H, Kimura T, Fukuda T, Shen JS, Shimada Y, Ida H, Eto Y, Ohashi T：Neonatal gene transfer using lentiviral vector for murine Pompe disease: long term expression and glycogen reduction. Gene Therapy.2010;17,521-30.
  6. Xing-Li Meng, Jin-Song Shen, Shiho Kawagoe, Toya Ohashi, Roscoe O Brady, Yoshikatu Eto : Induced pluripotent stem cells derived from mouse models of lysosomal storage disorders. PNAS 2010 vol.17(17):7886-7891.
  7. Okuyama T, Tanaka A, Suzuki Y, Ida H, Tanaka T, Cox GF, Eto Y, Orii T : Japan Elaprase Treatment (JET) study: idursulfase enzyme replacement therapy in adult patients with attenuated Hunter syndrome (Mucopolysaccharidosis II, MPS II). Mol Genet Metab. 2010 Jan; 99(1):18-25. Epub.
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東京慈恵会医科大学
遺伝病研究講座

〒105-8471
東京都港区西新橋3-25-8

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